Secondary Analyses of Alcohol and Chronic Disease (R03) | PA 16 394

Opportunity Information: Apply for PA 16 394

Secondary Analyses of Alcohol and Chronic Disease (R03) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number PA 16-394) designed to support small, focused research projects that use existing data to study how alcohol use relates to chronic disease. The central emphasis is on secondary analysis, meaning applicants are expected to rely on previously collected datasets rather than launching new, large-scale primary data collection efforts. The intent is to make research both innovative and cost-effective by leveraging established cohorts, surveys, clinical datasets, administrative data, registries, or other archived sources to answer new or refined questions about chronic disease etiology (causes and mechanisms) and epidemiology (patterns, risk factors, and population-level impacts).

The scientific scope is broadly framed around understanding links between alcohol exposure and chronic disease outcomes. Projects under this announcement would typically examine how alcohol consumption patterns, intensity, duration, age of initiation, binge drinking, alcohol use disorder, or related measures are associated with the development or progression of chronic conditions. Because the FOA highlights etiology and epidemiology, competitive applications generally fit questions such as risk relationships, dose-response patterns, subgroup differences, interactions with other exposures (like smoking, diet, medications, or social determinants of health), and population disparities. The R03 mechanism is intended for discrete, well-defined analyses that can be completed with modest resources, often including exploratory or hypothesis-generating work that can set the stage for larger future studies.

From an administrative standpoint, this opportunity is offered as a grant under NIH, within the funding activity categories of education and health, and is associated with CFDA numbers 93.273 and 93.399. The listed award ceiling is $50,000, signaling that awards are relatively small and targeted, consistent with the R03 small grant mechanism. The program was created on August 10, 2016, and the original closing date listed is September 7, 2019, which indicates the specific posting is historical, though similar NIH funding announcements may appear in other cycles or updated versions.

Eligibility is intentionally broad, reflecting NIH’s interest in attracting strong analytic proposals from many types of organizations. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled colleges and universities; private institutions of higher education; Native American tribal governments (federally recognized); public housing authorities/Indian housing authorities; tribal organizations that are not federally recognized governments; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other applicant types. The announcement also explicitly calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; and even non-U.S. entities (foreign organizations). This wide eligibility reflects the reality that valuable alcohol and chronic disease datasets exist across academic, governmental, healthcare, and community settings, and that policy-relevant findings can come from many sectors.

In practical terms, an application responding to this FOA would be expected to clearly identify the existing dataset(s) to be used, define alcohol-related exposures and chronic disease outcomes, lay out a rigorous analysis plan, and explain why the proposed secondary analyses are novel and meaningful given what is already known. Because the program’s purpose is to enable cost-effective work, proposals typically need to demonstrate strong feasibility: data access is secured or realistically obtainable, key variables are available, sample size is adequate for the planned analyses, and the analytic methods are appropriate for the study design and limitations of the dataset. Overall, the opportunity supports smaller-scale research intended to generate impactful insights about alcohol’s role in chronic disease using data that already exist, helping accelerate knowledge without the time and cost required to build new cohorts or collect new primary data.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Secondary Analyses of Alcohol and Chronic Disease (R03)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.399.
• This funding opportunity was created on 2016-08-10.
• Applicants must submit their applications by 2019-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $50,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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